Question Detail
Question
Philadelphia chromosome refers to the translocation between the long arms of
Correct Answer
Option C is the correct answer.
Detailed Explanation
The Philadelphia chromosome is an abnormally short chromosome 22 resulting from a reciprocal translocation between the long arms of chromosome 9 and chromosome 22, denoted as t(9;22)(q34;q11). This translocation fuses the BCR gene on chromosome 22 with the ABL1 gene on chromosome 9, creating a constitutively active tyrosine kinase. It is a hallmark of chronic myeloid leukemia (CML).
Hint
This chromosomal abnormality is a well-known marker for a specific type of leukemia.