Question Detail
Question
A form of chromosomal aberration that involves the fusion of long arms of acrocentric chromosomes at the centromere is known as
Correct Answer
Option C is the correct answer.
Detailed Explanation
Robertsonian translocation (also known as centromeric fusion) is a type of chromosomal rearrangement where two acrocentric chromosomes fuse at the centromere, resulting in one large metacentric chromosome and loss of the short arms. This is a common cause of Down syndrome when it involves chromosome 21. Reciprocal translocation involves exchange between non-homologous chromosomes, and an isochromosome has two identical arms.
Hint
This type of translocation is a common cause of Down syndrome and involves the fusion of two acrocentric chromosomes.