Question Detail

CHM 102 Fundamentals of Amines: Nomenclature, Isomerism, and Synthesis Objective Question
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Question

In the Gabriel synthesis, which reagent is used to alkylate phthalimide?
Options
A Alkyl halide
Correct Answer
B Alcohol
C Aldehyde
D Carboxylic acid
Correct Answer

Option A is the correct answer.

Detailed Explanation

Phthalimide is first deprotonated to form the phthalimide anion, which then undergoes SN2 reaction with an alkyl halide to form N-alkylphthalimide, then hydrolyzed to the primary amine.

Hint

Nucleophilic substitution on alkyl halide.

Question Info

Course: CHM 102
Topic: Fundamentals of Amines: Nomenclature, Isomerism, and Synthesis
Type: Objective
Difficulty: Not specified
Question 278 of 1999
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