Question Detail

BIO 201 Objective Question

Question

In parallel diagnostic studies, how does 'differential verification bias' distort trial findings?
Options
A By applying different reference standard tests depending on the index test result
Correct Answer
B By allowing clinical observers to re-evaluate samples after unblinding
C By enrolling healthy young controls and severely ill cases exclusively
D By changing assay reagents midway through cohort processing
Correct Answer

Option A is the correct answer.

Detailed Explanation

Differential verification bias occurs when patients testing positive on the index test undergo a different (e.g., more invasive) reference standard than those testing negative.

Hint

No hint available

Question Info