Question Detail

BIO 201 Objective Question

Question

In a parallel comparative study evaluating two diagnostic kits (Kit A and Kit B), what constitutes verification (work-up) bias?
Options
A When only samples testing positive on Kit A are sent for verification by the gold standard reference.
Correct Answer
B When both positive and negative samples undergo independent gold standard verification.
C When parallel controls exhibit unexpected signal degradation.
D When the study uses non-parametric statistical tests to calculate p-values.
Correct Answer

Option A is the correct answer.

Detailed Explanation

Verification bias occurs when the decision to perform the reference standard depends on the preliminary test outcome, artificially skewing sensitivity/specificity.

Hint

No hint available

Question Info