Question Detail

BIO 201 Objective Question
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Question

In parallel mass spectrometry diagnostic workflows, why are stable isotope-labeled internal standards (SIL-IS) added to samples?
Options
A They chemical behave identically to target analytes, correcting for ionization suppression and sample extraction losses.
Correct Answer
B They permanently quench unwanted matrix background fluorescence.
C They alter the chromatographic retention time of target compounds.
D They act as enzymatic inhibitors to stabilize labile plasma metabolites.
Correct Answer

Option A is the correct answer.

Detailed Explanation

SIL-IS molecules share physical-chemical properties with the target analyte, providing ideal compensation for recovery losses and matrix effects during LC-MS analysis.

Hint

No hint available

Question Info

Course: BIO 201
Type: Objective
Difficulty: Not specified
Question 128 of 285
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