Question Detail

BIO 201 Objective Question
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Question

In a parallel diagnostic trial, what primary challenge arises when the reference standard ('gold standard') is imperfect?
Options
A True positive index test results may be misclassified as false positives, underestimating test performance.
Correct Answer
B The index test sensitivity automatically reaches 100% mathematical limit.
C Negative predictive values become completely independent of target disease prevalence.
D Assay incubation times must be increased to achieve thermodynamic equilibrium.
Correct Answer

Option A is the correct answer.

Detailed Explanation

If the reference standard itself makes diagnostic errors, a accurate index test will be wrongly penalized for disagreeing with incorrect reference outputs.

Hint

No hint available

Question Info

Course: BIO 201
Type: Objective
Difficulty: Not specified
Question 140 of 285
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