Question Detail
Question
Match List I (Disease) with List II (Description) and select the correct answer using the code given below the lists: List I A. Down's syndrome B. Albinism C. Maple syrup urine disease List II 1. Congenital absence of tyrosinase 2. Lack of amino acid decarboxylase 3. Trisomy of chromosome 21
Correct Answer
Option B is the correct answer.
Detailed Explanation
Down's syndrome (trisomy 21) is caused by trisomy of chromosome 21 (A-3). Albinism (oculocutaneous albinism) is caused by congenital absence or deficiency of tyrosinase (B-1), the enzyme involved in melanin synthesis. Maple syrup urine disease (MSUD) is caused by deficiency of the branched-chain alpha-keto acid dehydrogenase complex (an amino acid decarboxylase) (C-2), leading to accumulation of branched-chain amino acids.
Hint
Match each genetic disorder to its correct biochemical or chromosomal basis.