Question Detail
Question
Assertion (A): Spontaneous mutation involves base pair substitutions during DNA replication. Reason (R): It is a temperature sensitive mutation and changes the base pair.
Correct Answer
Option C is the correct answer.
Detailed Explanation
Assertion A is true: Spontaneous mutations can arise from base pair substitutions during DNA replication due to tautomeric shifts, replication errors, or depurination. Reason R is false: Spontaneous mutations are not inherently temperature-sensitive mutations. Temperature sensitivity is a specific property of some mutant alleles (conditional mutations) that are expressed only at certain temperatures. Spontaneous mutations are not defined by temperature sensitivity.
Hint
Distinguish between the causes of spontaneous mutations and the concept of conditional (temperature-sensitive) mutations.