Question Detail

CHM 102 Fundamentals of Amines: Nomenclature, Isomerism, and Synthesis Objective Question
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Question

Which reducing agent is commonly used in reductive amination of aldehydes/ketones to amines?
Options
A LiAlH4
B NaBH4
C NaBH3CN (sodium cyanoborohydride)
Correct Answer
D H2/Ni
Correct Answer

Option C is the correct answer.

Detailed Explanation

Sodium cyanoborohydride (NaBH3CN) is selective for reductive amination because it reduces iminium ions at pH ~6-7 without reducing aldehydes/ketones rapidly under those conditions.

Hint

Works well at mildly acidic pH.

Question Info

Course: CHM 102
Topic: Fundamentals of Amines: Nomenclature, Isomerism, and Synthesis
Type: Objective
Difficulty: Not specified
Question 256 of 1999
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