Question Detail

CHM 102 Carboxylic Acid Derivatives: Nomenclature, Synthesis, and Reactions Objective Question
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Question

Which of the following is the most reactive toward nucleophilic acyl substitution?
Options
A Amide
B Ester
C Acid chloride
Correct Answer
D Anhydride
Correct Answer

Option C is the correct answer.

Detailed Explanation

Reactivity order: acid chlorides > anhydrides > esters ≈ carboxylic acids > amides. Chloride is the best leaving group.

Hint

Chloride is a good leaving group.

Question Info

Course: CHM 102
Topic: Carboxylic Acid Derivatives: Nomenclature, Synthesis, and Reactions
Type: Objective
Difficulty: Not specified
Question 301 of 1999
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