Question Detail

CHM 102 Carboxylic Acid Derivatives: Nomenclature, Synthesis, and Reactions Objective Question
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Question

What is the leaving group in an amide during nucleophilic acyl substitution?
Options
A Cl-
B OH-
C NH2- (amide ion)
Correct Answer
D OR-
Correct Answer

Option C is the correct answer.

Detailed Explanation

NH2- (amide ion) is a very poor leaving group, which makes amides the least reactive carboxylic acid derivatives.

Hint

Poor leaving group = low reactivity.

Question Info

Course: CHM 102
Topic: Carboxylic Acid Derivatives: Nomenclature, Synthesis, and Reactions
Type: Objective
Difficulty: Not specified
Question 302 of 1999
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