Question Detail

BIO 201 Objective Question
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Question

Why is sample size calculation essential prior to conducting a parallel diagnostic accuracy trial?
Options
A To ensure sufficient statistical power to estimate sensitivity and specificity within acceptable confidence intervals
Correct Answer
B To guarantee that the index test reaches 100% analytical sensitivity
C To eliminate all potential sources of pre-analytical laboratory error
D To force the disease prevalence in the sample to equal 50%
Correct Answer

Option A is the correct answer.

Detailed Explanation

Calculating sample size ensures the study enrolls enough true positive and true negative subjects to achieve narrow, clinically meaningful 95% confidence intervals.

Hint

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Question Info

Course: BIO 201
Type: Objective
Difficulty: Not specified
Question 48 of 285
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